Want to keep track of the largest startup funding deals in 2026 with our curated list of $100 million-plus venture deals to U.S.-based companies? Check out The Crunchbase Megadeals Board.

This is a weekly feature that runs down the week’s Top 10 announced funding rounds in the U.S. Check out last week’s biggest funding deal roundup here.

Startup investors aren’t exactly hitting pause, but they did scale back on giant rounds this past week, with just two startup financings in the multiple hundreds of millions. The biggest round went to AI infrastructure provider Modal Labs, which picked up $750 million, followed by construction automation unicorn Icon, which secured $200 million. Other sectors that attracted larger rounds this past week included biotech, insurance and AI.

1. Modal Labs, $750M, AI infrastructure: Modal Labs, a provider of cloud infrastructure for AI inference and other applications, secured $750 million in a Series D funding round led by Accel at a $15.75 billion valuation. The New York-headquartered company said it recently exceeded an annual revenue run rate of $1 billion.

2. Icon, $200M, construction tech: Austin-based Icon, a developer of robotic construction systems known for its 3D-printed homes, closed on $200 million in Series D funding led by Baillie Gifford and BlackRock. The company says it is on pace for 4x revenue growth in 2026.

3. Soufflé Therapeutics, $135M, RNA therapies: Boston-based Soufflé Therapeutics, a developer of RNA therapies, raised $135 million in Series B funding led by Juvia Group as part of a large syndicate of investors.

4. Estuary Biotherapeutics, $103M, gene therapies: Menlo Park, California-based Estuary Biotherapeutics, a developer of genetic medicines for patients with serious kidney diseases, launched with $103 million in financing. The funding includes $93 million in a Series A round led by RA Capital Management as well as $10 million in previously undisclosed seed capital.

5. Labelbox, $100M, AI tools: Labelbox, a developer of technology to train and evaluate AI models and to help deploy agents that improve with experience, picked up $100 million in Series E funding. Infinitum Partners led the financing for the 8-year-old, San Francisco-based company.

6. Suki, $90M, health AI: Redwood City, California-based Suki, a provider of AI tools that turn clinical conversations into intelligence for documentation, coding and other healthcare workflows, announced a $90 million Series E financing from backers including Healthier Capital and Crosslink Capital.

7. Abby Care, $82M, caregiver platform: Abby Care, a platform for family members to become certified, paid caregivers and deliver care at home, closed on $82 million in Series C funding, per a Fortune report. Transformation Capital led the financing for the 5-year-old, San Francisco-based startup.

8. Stand, $70M, insurance: Stand, a provider of insurance for homes in areas at higher risk of natural disasters, secured $70 million in Series C funding at a $1 billion valuation. Saga Ventures led the financing for the 3-year-old, San Francisco-based company.

9. Mueon, $65M, semiconductor systems: Mueon Corp., a semiconductor systems company building a modular platform for AI and hyperscale computing, completed a $65 million Series A funding round. Maverick Silicon led the financing for the Portland, Oregon-based company.

10. North.cloud, $60M, AI spend management: New York-based North.cloud, provider of an infrastructure spend intelligence and automation platform, raised $60 million in a Series B round led by PeakSpan Capital.

Methodology

We tracked the largest announced rounds in the Crunchbase database that were raised by U.S.-based companies for the period of Oct. 10-16, 2026. Although most announced rounds are in the database, there may be a small time lag, as some rounds are reported late in the week.

Illustration: Dom Guzman