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Why large dogs age faster

In many mammalian species, larger creatures tend to have longer lifespans. Mice, for instance, live an average of just two years, while some whales can last for as long as 200 years. Dogs, however, buck this pattern; larger dogs tend to age faster and die younger than smaller ones, which makes canines an ideal model for biologists to study to learn more about aging in general. Arizona State University scientists report that these lifespan differences seem to be due to so-called "jumping genes," according to a paper published in the journal Science.

The authors used data from 864 dogs collected in the Dog Aging Project to map patterns of DNA methylation (which influences how much certain genes are turned on or off) across the entire genome. It's part of the epigenome, whose markers can change over time in response to stress and other environmental factors. Genetic sequences, by contrast, are largely fixed. So DNA methylation is a good chemical indicator of aging and DNA regulation.

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